Glioblastoma multiforme (GBM) is the most common brain tumor, accounting for about half of central nervous system tumors. GBM is a subtype of astrocytoma, with high aggressiveness and lethality, characterized by intense anaplasia and presence of necrosis. In general, treatment for GBM involves surgery, followed by radiotherapy and chemotherapy. To learn more about the treatment of tumors of the central nervous system, see the section “Tumors of the CNS”.