10ª Edição

MRI scan followed by directed biopsy is not inferior to initial systemic biopsy in men with suspected prostate cancer

per: Grupo Oncoclínicas
MRI scan followed by directed biopsy is not inferior to initial systemic biopsy in men with suspected prostate cancer

Scientific commission

André Fay
André Fay
Carlos Augusto Vasconcelos
Carlos Augusto Vasconcelos
Diogo Rosa
Diogo Rosa
Luiz Flávio Coutinho
Luiz Flávio Coutinho

Contributors

Pedro Abreu
Pedro Abreu

This multicenter, prospective, randomized clinical study was carried out in five Canadian health science academic centers, between January 2017 and November 2019. Participants included men without biopsy history with suspected prostate cancer, who were advised to undergo the procedure.

The sample for treatment consisted of 453 patients, randomized for biopsy procedure or MRI scan with biopsy direction. Lesions with 3 or higher PI-RADS scores were found in 138 of 221 men (62,4%). Cancer detection among group 1 was reduced by more than half among the MRI scan branch. Pedro Abreu, Rio de Janeiro Oncoclinicas oncologist, informs that the study reached its primary goal, with clinically significant prostate cancer diagnosis in 35% of patients in the group with biopsies directed by MR (MR-TBx) versus 30% in the group with randomized biopsy through TRUS (TRUS-Bx). “However, NMR-TBx did not prove superior to sonogram through biopsy”, he highlights. “A total of 79 MR group patients (37%) avoided an unnecessary biopsy and prostate cancer diagnosis ISUP 1 declined by more than 50% among the MR group.”

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