The androgen receptor is a existing protein in the nucleus of certain cells to which some female hormones (the estrogens) bind. This receptor is normally found on the ovary and endometrium cells.

The binding of estrogens to their receptor occurs thanks to the structural complementarity between these molecules, as in a key and lock system.This binding leads to a series of chemical reactions that culminate in the expression of certain genes.

In the case of breast cancer, this expression translates into cell proliferation. Thus, it is said that breast cancer is dependent on female hormones for its development and progression, whenever there is expression of estrogen receptors. For this reason, hormone therapy is employed in these cases. To find out more about breast cancer, please see the section “Breast Cancer”. To find out more about hormone therapy, see the section “Frequently Asked Questions – Hormone Therapy”.

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This content is part of the Oncoclínicas glossary with all terms related to Oncology and its treatments.
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