Changing trends in the treatment of brain metastasis was the subject of a study at ESMO 2020
A study presented at this year’s ESMO Virtual Congress analyzed a group of 6,001 patients diagnosed with brain metastasis between 1986 and 2020. The data point to some changing trends in treatment, such as the increased use of systemic therapies and radiosurgery. In addition, they indicate an increase in survival over the years, as well as an improvement in the quality of prognoses, which have become more accurate with the use of molecular markers. The research also points to an increase in the frequency of stereotactic radiosurgery. Oncologist Sabrina Cristofaro, a member of the team at Centro de Tratamento Oncológico Ipanema, an Oncoclinicas Group clinic in Rio de Janeiro, explains that radiosurgery involves the use of high doses of radiation locally on the lesion. “In the past, we used to do whole-brain radiotherapy, which was applied to the whole skull. This radiotherapy had a lower dose, but a very wide field, which caused a decrease in cognition and a worsening in quality of life, among other problems”, he says. This led to a search for new alternatives, which led to the development of radiosurgery.
“Classically, radiosurgery was indicated for patients with up to three lesions of up to 3 centimeters,” explains Camila Martins Fonseca Galizzi, oncologist at Onconcentro Belo Horizonte, an Oncoclíncias clinic in Minas Gerais. “Today, however, this decision is made case by case, and the fact of having more lesions does not, by itself, contraindicate the performance of radiosurgery,” she says.
Read below, the complete report.